Severe lactic acidosis reversed by thiamine within 24 hours

iamine is a water-soluble vitamin that plays a pivotal role in carbohydrate metabolism. In acute defi ciency, pyruvate accumulates and is metabolized to lactate, and chronic defi ciency may cause polyneuropathy and Wernicke encephalopathy. Classic symptoms include mental status change, ophthalmoplegia, and ataxia but are present in only a few patients [1]. Critically ill patients are prone to thiamine defi ciency because of preexistent malnutrition, increased consumption in high-carbohydrate nutrition, and accelerated clearance in renal replacement. In retrospective [2] and prospective [3,4] studies, a substantial prevalence of thiamine defi ciency has been described in both adult (10% to 20%) and pediatric (28%) patients. Th iamine defi ciency may become clinically evident in any type of malnutrition that outlasts thiamine body stores (2 to 3 weeks), including alcoholism, bariatric surgery, or hyperemesis gravidarum, and results in high morbidity and mortality if untreated [1]. We report the case of a 56-year-old man with profound lactic acidosis that resolved rapidly after thiamine infusion. He was admitted because of a decreased level of consciousness (Glasgow Coma Scale score of 6). Vital signs, including blood pressure, heart rate, and oxygen saturation, were normal. Besides reporting regular alcohol consumption, relatives reported recent progressive weakness and 5-kg weight loss. Laboratory fi ndings on admission were remarkable for moderate hypo glycemia and metabolic acidosis – pH of 6.87, base excess of –29.5, partial pressure of carbon dioxide (pCO2) of 14 mm Hg – with a high anion gap (37 mmol/L) that was attributed to severe hyperlactatemia (21 mmol/L). After intravenous glucose administration, the patient was transferred to the intensive care unit, where he received sodium bicarbonate and 1,500 mL of lactate-free isotonic crystalloids. Within the next few hours, lactate levels increased further while pH slowly improved. Clinically, thiamine defi ciency was suspected after other causes of hyperlactatemia, such as hypoxia and hepatic failure, were excluded. After administration of 300 mg of intravenous thiamine, hyper lactatemia normalized rapidly (Figure 1). Unfortunately, the patient suff ered persistent neurocognitive defi cits. Th iamine defi ciency may cause unspecifi c neurologic symptoms. Glucose administration or feeding may aggravate depletion. Th iamine defi ciency is an underdiagnosed cause of lactic acidosis, although treatment is safe, inexpensive, and readily available. Current guidelines on parenteral nutrition recommend a daily intravenous dose of 100 to 300 mg of thiamine during the fi rst 3 days in the intensive care unit when defi ciency is a possibility (grade B) [5]. In conclusion, although its clinical signifi cance has been known for decades, thiamine defi ciency remains an under-recognized condition. Intensivists should have an increased awareness of this problem and a low threshold to infuse high-dose thiamine. Future prospective studies to defi ne the optimal dose and duration of treatment are warranted.